Author

James Staley

UCB Pharma (United Kingdom)

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Biology Disciplines

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Bioinformatics· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:statistical model· 1

Frequent Co-Authors

Andrew J. SkeltoniD· 1 shared Jiaqi GuiD· 1 shared Juliet K. KnowlesiD· 1 shared Lei Peng· 1 shared Pierce Oran Popson· 1 shared Xiaoyu SongiD· 1 shared Zihuai HeiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 21 mutual co-author links

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1 shared paperBioinformatics

Andrew J. SkeltonORCID

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1 paper

Recent·Most cited

Distilling Direct Effects via Conditional Differential Gene Expression Analysis

Jiaqi Gu, Andrew J. Skelton, James Staley, Pierce Oran Popson, Lei Peng, Xiaoyu Song, Juliet K. Knowles, Zihuai He

The paper introduces conditional differential gene expression analysis to distinguish direct from mediated gene effects in RNA sequencing data, finding most differentially expressed genes are not directly causal.

bioRxiv · Sep 29, 2025 · PreprintBioinformatics