Andrew J. Skelton

The paper introduces conditional differential gene expression analysis to distinguish direct from mediated gene effects in RNA sequencing data, finding most differentially expressed genes are not directly causal.

The paper identifies miR-140-3p as more abundant in human cartilage and shows its isomiRs have distinct functional targets.

The paper identifies DNA hypomethylation during MSC chondrogenesis, particularly at enhancer regions, and links these changes to the chondrocyte phenotype and cartilage disease.