Mouse brain-wide transgene expression by systemic injection of genetically engineered exosomes: CAP-Exosomes
Saumyendra N. Sarkar, Deborah R. Corbin, James W. Simpkins
The paper develops CAP-exosomes for systemic brain-targeted gene delivery, showing 20-fold higher GFP transduction efficiency in the CNS compared to control exosomes.
bioRxiv · Apr 6, 2022 · PreprintNeuroscience