Dissection of ergosterol metabolism reveals a pathway optimized for membrane phase separation
Israel Juarez-Contreras, Laura J. S. Lopes, Jamie Holt, Lorena Yu-Liao, Katherine O’Shea, Jose Ruiz-Ruiz, Alexander J. Sodt, Itay Budin
The paper analyzes ergosterol metabolism in yeast to show how successive modifications balance lipid ordering and fluidity for membrane phase separation.
bioRxiv · Jan 5, 2025 · PreprintBiophysics