Itay Budin

This paper measures how hydrostatic pressure affects lipid mixing rates during membrane fusion, showing a linear relationship between lipid curvature and energy required for hemifusion stalk formation.

The paper shows that ether linkages in phospholipids modulate membrane mechanics and topology through distinct physical mechanisms, explaining their evolutionary conservation and biological roles.

This paper investigates how sterol structure and sphingolipid chain length influence membrane order and phase behavior in yeast vacuole membranes.

A pectin-based formulation preserves milk fat globule membranes in stored human milk, reducing lipase-driven degradation and maintaining sensory quality.

This study shows that saturated cardiolipins (CLsat) disrupt inner mitochondrial membrane structure and function, contributing to mitochondrial dysfunction in Barth syndrome.

The paper identifies Npc2's role in sphingolipid transport to the yeast vacuole, showing it supports membrane phase separation during micro-lipophagy.

This study investigates how 1-deoxysphingolipids affect membrane properties and cargo trafficking in the early secretory pathway by analyzing their subcellular distribution and effects on ER membrane fluidity and ERES.

This study shows eukaryotic cells maintain lipid curvature homeostasis under pressure through metabolic adjustments, with yeast and human cells using different mechanisms.

This paper introduces FACES, a tool for imaging lipid pools and transbilayer orientation in living cells, and applies it to study lipid transfer proteins and membrane asymmetry.

The paper identifies a phospholipid transporter in Asgard archaea with structural and functional similarities to eukaryotic LTPs, suggesting lipid transport mechanisms predate eukaryogenesis.

The paper identifies LPCAT3 as a cold-regulated enzyme that generates AA-PE in BAT mitochondria, enhancing ETC efficiency and thermogenesis.

The paper uses molecular dynamics simulations to show cardiolipin increases membrane spontaneous curvature and reduces bending rigidity, leading to lateral heterogeneities through curvature sensing.

The paper analyzes ergosterol metabolism in yeast to show how successive modifications balance lipid ordering and fluidity for membrane phase separation.

This study develops organelle-targeted Laurdan probes to measure membrane packing heterogeneity and responses to saturated lipid stress in specific cellular compartments.

This study shows that cardiolipin remodeling is essential for maintaining inner mitochondrial membrane structure in yeast under low oxygen conditions and identifies Ddl1p as a regulator of CL levels.