Elucidating the half-site reactivity mechanism of Salmonella enterica FraB deglycase using native mass spectrometry
Yuan Gao, Jamison D. Law, Venkat Gopalan, Vicki Hopper Wysocki
This study uses native mass spectrometry to reveal the half-site reactivity mechanism of Salmonella FraB, showing how substrate binding and conformational changes regulate catalytic activity in a homodimeric enzyme.
bioRxiv · Jul 20, 2026 · PreprintBiochemistry