Loss of the homologous recombination gene rad51 leads to Fanconi anemia-like symptoms in zebrafish
Jan Gregor Botthof, Ewa Bielczyk-Maczyńska, Lauren Ferreira, Ana Cvejic
This paper establishes a zebrafish rad51 loss-of-function model that recapitulates Fanconi anemia symptoms, showing hematopoietic defects and tumor predisposition upon p53 co-mutation.
Proceedings of the National Academy of Sciences · May 16, 2017Peer-reviewedGenetics