Patterns of structural variation in human cancer
Yilong Li, Nicola D Roberts, Joachim Weischenfeldt, Jeremiah A Wala, Ofer Shapira, Steven E. Schumacher, Ekta Khurana, Jan Korbel, Marcin Imielinski, Rameen Beroukhim, Peter J Campbell, on behalf of the PCAWG-Structural Variation Working Group, and the PCAWG Network
The paper identifies nine structural variation signatures in cancer genomes, revealing patterns of deletions, tandem duplications, and translocations linked to replication mechanisms and oncogenic activation.
bioRxiv · Aug 27, 2017 · PreprintCancer Biology