Leveraging zebrafish embryo phenotypic observations to advance data-driven analyses in toxicology
Paul Michaelis, Nils Klüver, Silke Aulhorn, Hannes Bohring, Jan Bumberger, Kristina Haase, Tobias Kuhnert, Eberhard Küster, Janet Krüger, Till Luckenbach, Riccardo Massei, Lukas Nerlich, Sven Petruschke, Thomas Schnicke, Anton Schnurpel, , Wibke Busch
A structured zebrafish embryo toxicity database (INTOB, 638 experiments) enabled control-quality tests, dose-response modeling and phenotype-fingerprint clustering of 47 substances (133 experiments); literature data proved unsuitable for meta-analysis.
Environmental Science & Technology · Feb 27, 2025Peer-reviewedPharmacology & Toxicology✦ In-depth digest