A functional genomic screen in Saccharomyces cerevisiae reveals divergent mechanisms of resistance to different alkylphosphocholine chemotherapeutic agents.
Jaquelin M Garcia, Michael J. Schwabe, Dennis R. Voelker, Wayne Russell Riekhof
The paper identifies yeast gene mutants resistant to miltefosine, revealing roles for vesicular transport and ER-plasma membrane contact sites in drug action.
G3 Genes Genomes Genetics · Aug 10, 2021Peer-reviewedGenetics