Characterization of a cofilin mutant with high actin bundling activity in living cells
Bruno F Pizani, Leanna M Dover, Michelle Cobb, Jarrett Lloyd, Jordan M. Hardeman, Karen Litwa, Robert M. Hughes
This study investigates the role of cofilin S119 in actin dynamics by mutating it to aromatic amino acids, showing increased actin bundling and effects on neuronal spines and apoptosis.
bioRxiv · Apr 30, 2026 · PreprintCell Biology