S100A1's single cysteine is an indispensable redox-switch for the protection against diastolic calcium leakage in cardiomyocytes
Andreas Seitz, Martin Busch, Jasmin Kroemer, Andrea Schneider, Stephanie Simon, Andreas Jungmann, Hugo Albert Katus, Julia Ritterhoff, Patrick Most
This study identifies S100A1's C85 residue as a redox-switch critical for preventing diastolic calcium leakage in cardiomyocytes, without affecting inotropic function.
American Journal of Physiology-Heart and Circulatory Physiology · May 31, 2024Peer-reviewedMolecular Biology