Hugo Albert Katus

The paper examines the relationship between the ER and SR in cardiac myocytes, finding that the SR becomes the primary site of protein synthesis in adult cells, while the ER retains specialized functions.

This study shows that HDAC inhibition with SAHA reduces doxorubicin-induced cardiotoxicity by modulating Topo IIb and MEF2-dependent transcription.

This study identifies S100A1's C85 residue as a redox-switch critical for preventing diastolic calcium leakage in cardiomyocytes, without affecting inotropic function.

This study shows that temporarily inhibiting protein translation after heart attack reduces inflammation and improves long-term heart function by targeting the mTORC1-4EBP1-eIF4F pathway.

The paper identifies a SNP in lncRNA H19 that alters its secondary structure and is associated with Dilated Cardiomyopathy, suggesting structural changes in lncRNAs may explain hidden genetic variance.

This study shows that the unfolded protein response declines with age in the heart, leading to protein misfolding and cardiac dysfunction.

The paper identifies Cand2 as an mTORC1-regulated gene that promotes adverse cardiac remodeling when overexpressed, and shows its deletion protects the myocardium.

The paper compares transcriptome and translatome networks in cardiac remodeling to identify differences in gene regulation and functional modules.

The paper identifies extracellular vesicles (EVs) as a mechanism for transporting BMP2/4 during zebrafish embryonic development, leading to dorsalization phenotypes when EV secretion is inhibited.