IGF1R-Targeted Delivery of a Bridged Nucleic Acid Oligonucleotide-Peptide Conjugate for MicroRNA 21 Inhibition in Triple-Negative Breast Cancer
Yuanyuan Jin, Vilas Desai, Jason Mazzaroth, Eric Wickstrom
This study develops an IGF1R-targeted miR-21 inhibitor conjugate that reduces TNBC cell proliferation, induces apoptosis, and shows tumor-specific efficacy in mice with minimal toxicity.
NAR Cancer · Oct 7, 2025Peer-reviewedCancer Biology