Inference of single cell profiles from histology stains with the Single-Cell omics from Histology Analysis Framework (SCHAF)
Charles S. Comiter, Xingjian Chen, Eeshit Dhaval Vaishnav, Koseki J. Kobayashi-Kirschvink, Metamia Ciampricotti, Ke Zhang, Jason Murray, Francesco Monticolo, Jianhuan Qi, Ryota Tanaka, Sonia E. Brodowska, Bo Li, Yiming Yang, Scott J. Rodig, Angeliki Karatza, , Aviv Regev
SCHAF generates spatially resolved single-cell transcriptomes from H&E histology images using vision transformers and adversarial learning, showing good agreement with ground-truth data.
bioRxiv · Mar 21, 2023 · PreprintBioinformatics