VIP-OT: Dissecting Single-Cell Biochemical State Dynamics under Perturbation via Vibrational Painting and Optimal Transport
Xuemeng Li, Stefan G. Stark, Xinwen Liu, Mian Wei, Zhilun Zhao, Jianhuan Qi, Xingjian Chen, Thai Nam Son Dang, Yinghan Wu, Ke Zhang, Wei Min, Jian Shu
VIP-OT traces drug response heterogeneity in single cells using vibrational imaging and optimal transport to predict post-treatment metabolic states from pre-treatment spectra.
bioRxiv · Dec 12, 2025 · PreprintBioengineering