Early ingestive experience with a high-fat diet tunes satiation and nutrient-specific appetitive behaviors
Meaghan E. McCoy, Ciorana Roman-Ortiz, Jason Perez, Lindsey A. Schier, Anna K. Kamitakahara
This study shows that early exposure to a high-fat diet in mice leads to premature maturation of satiation responses and lasting changes in appetitive behaviors, with sex-specific effects on overconsumption of calorie-dense foods.
bioRxiv · Aug 19, 2026 · PreprintAnimal Behavior & Cognition