LDL receptor-mediated endocytosis of Escherichia coli α-hemolysin mediates renal epithelial toxicity
Hunter W. Kuhn, Madeleine R. Smither, Rachel J. Jin, Christina A. Collins, Hongming Ma, Jason Sina, Joseph P. Gaut, Michael Diamond, David A. Hunstad
This study identifies LDLR-mediated clathrin-dependent endocytosis as the mechanism by which HlyA from UPEC causes renal epithelial toxicity.
Proceedings of the National Academy of Sciences · Jun 12, 2025Peer-reviewedMicrobiology