The Role of Chloride Ions in Serotonin Transport
Jiahui Huang, Angela Bäcker, Stacy Uchendu, Bethlehem Bekele, Chan Li, Qingyang Chen, Esam A. Orabi, Robyn Stix, Jasper D. Shide, Yuan‐Wei Zhang, Gary Rudnick, Eva Hellsberg, Lucy R. Forrest
This study investigates the role of chloride ions in serotonin transport, showing they do not drive uptake but stabilize transporter conformations by enhancing sodium binding and helix packing.
Proceedings of the National Academy of Sciences · Aug 24, 2026Peer-reviewedBiochemistry