Author

Esam A. Orabi

National Institutes of HealthORCID 0000-0002-5338-9203Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Assay:structural biology· 1

Frequent Co-Authors

Robyn StixiD· 2 shared Angela BäckeriD· 1 shared Bethlehem BekeleiD· 1 shared Chan LiiD· 1 shared Eva HellsbergiD· 1 shared Gary RudnickiD· 1 shared Jasper D. Shide· 1 shared Jiahui HuangiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiochemistry

Robyn StixORCID

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2 papers

Recent·Most cited

The Role of Chloride Ions in Serotonin Transport

Jiahui Huang, Angela Bäcker, Stacy Uchendu, Bethlehem Bekele, Chan Li, Qingyang Chen, Esam A. Orabi, Robyn Stix, Jasper D. Shide, Yuan‐Wei Zhang, Gary Rudnick, Eva Hellsberg, Lucy R. Forrest

This study investigates the role of chloride ions in serotonin transport, showing they do not drive uptake but stabilize transporter conformations by enhancing sodium binding and helix packing.

Proceedings of the National Academy of Sciences · Aug 24, 2026Peer-reviewedBiochemistry

Distinct mechanisms of inhibition of Kv2 potassium channels by tetraethylammonium and RY785

Shan Zhang, Robyn Stix, Esam A. Orabi, Nathan A. Bernhardt, José D. Faraldo‐Gómez

This paper uses molecular dynamics simulations to compare how RY785 and TEA inhibit Kv2.1 channels, showing RY785 stabilizes a semi-open gate state while TEA blocks the pore.

bioRxiv · Jul 25, 2024Biochemistry