Author

Yuan‐Wei Zhang

Guangzhou UniversityORCID 0000-0002-4276-9251Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Angela BäckeriD· 1 shared Bethlehem BekeleiD· 1 shared Chan LiiD· 1 shared Chuntong YiniD· 1 shared D M WeiiD· 1 shared Esam A. OrabiiD· 1 shared Eva HellsbergiD· 1 shared Fang WangiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiochemistry

Angela BäckerORCID

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2 papers

Recent·Most cited

The Role of Chloride Ions in Serotonin Transport

Jiahui Huang, Angela Bäcker, Stacy Uchendu, Bethlehem Bekele, Chan Li, Qingyang Chen, Esam A. Orabi, Robyn Stix, Jasper D. Shide, Yuan‐Wei Zhang, Gary Rudnick, Eva Hellsberg, Lucy R. Forrest

This study investigates the role of chloride ions in serotonin transport, showing they do not drive uptake but stabilize transporter conformations by enhancing sodium binding and helix packing.

Proceedings of the National Academy of Sciences · Aug 24, 2026Peer-reviewedBiochemistry

High glucose confers senescence resistance via GLUT1 epigenetic rewiring to blunt immunotherapy responses in esophageal squamous cell carcinoma

Jinxiu Dong, Jie Zhou, Jia‐Jie Hao, Shuai Kong, Chuntong Yin, D M Wei, Fang Wang, Junboya Ma, Jinman Fang, Yuan‐Wei Zhang, 潘华光, Wenqiang Wei, M Wang, Kai Ma, Y Jiang, Yan‐Yi Jiang

This study identifies GLUT1 as a driver of immunotherapy resistance in ESCC by epigenetically suppressing senescence and reveals dietary glucose restriction as a potential strategy to enhance immunotherapy efficacy.

bioRxiv · Jul 16, 2026 · PreprintCancer Biology