Cell BiologybioRxivPreprint
Electrical Excitability of the Endoplasmic Reticulum Membrane Drives Electrical Bursting and the Pulsatile Secretion of Insulin in a Pancreatic Beta Cell Model
This paper proposes a mathematical model suggesting that electrical activity in the endoplasmic reticulum (ER) membrane drives electrical bursting and pulsatile insulin secretion in pancreatic beta cells, linking ER dynamics to diabetes pathogenesis.
DOI 10.1101/249805