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Jay Y. Paranjpe

McGill University

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Pharmacology & Toxicology· 1

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Approach:machine learning (classical)· 1 Approach:mixed model· 1 Approach:statistical model· 1

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Aaron Cho· 1 shared Andréi S. RodiniD· 1 shared Franziska M. HeydenreichiD· 1 shared Hanyu CheniD· 1 shared Nagarajan VaidehiiD· 1 shared Sergio BranciamoreiD· 1 shared Stéphane A. LaporteiD· 1 shared Tegvir S Boora· 1 shared

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1 shared paperPharmacology & Toxicology

Aaron Cho

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1 paper

Recent·Most cited

Pharmacology & ToxicologybioRxivPreprintSep 3, 2026

Allosteric pathways govern Gα protein coupling selectivity at promiscuous GPCRs

Tegvir S Boora, Hanyu Chen, Aaron Cho…·Stéphane A. Laporte

The paper identifies allosteric pathways that determine G protein coupling selectivity in promiscuous GPCRs using a combination of mutagenesis, simulations, and machine learning.

DOI 10.64898/2026.08.28.747882

machine learning (classical)statistical model