Stéphane A. Laporte

The paper identifies allosteric pathways that determine G protein coupling selectivity in promiscuous GPCRs using a combination of mutagenesis, simulations, and machine learning.

The paper develops an interpretable machine learning model to identify allosteric modulators of the AT1R receptor and discovers a negative allosteric modulator.

This study shows ACKR3 is released on extracellular vesicles under both basal and ligand-induced conditions, sequestering chemokines and opioid peptides and modulating their signaling.

This study identifies AngII analogs with modified C-terminal peptides that selectively engage Gq or β-arrestin pathways, showing differential effects on cardiac function and blood pressure in rats.

This paper develops a genetically encoded melanocortin sensor, FLAREMC, for high sensitivity intravital imaging of melanocortin signaling in vivo.

This paper optimizes the prostaglandin F2α receptor (FP) for structural biology by improving its purification yield and in vitro stability through protein engineering.