Maturing Mycobacterial Peptidoglycan Requires Non-canonical Crosslinks to Maintain Shape
Catherine Baranowski, Michael A. Welsh, Lok-To Sham, Haig A. Eskandarian, Hoong C. Lim, Karen J. Kieser, Jeffrey C. Wagner, John D. McKinney, Georg E. Fantner, Thomas R. Ioerger, Suzanne Walker, Thomas G. Bernhardt, Eric J. Rubin, E. Hesper Rego
The paper shows that LDT-mediated crosslinks in mycobacteria are crucial for maintaining rod shape at aging cell wall sites, and their absence makes Mtb more susceptible to combined PBP and LDT-inhibiting drugs.
bioRxiv · Apr 20, 2018 · PreprintMicrobiology