Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain
Cassandra Carol Taber, Wenguang He, Geneviève M. C. Gasmi-Seabrook, Mia Hubert, Fraser G. Ferens, Mitsuhiko Ikura, Jeffrey E Lee, Michael Ohh
The paper identifies PHD2 mutations that affect N-terminal prolyl-hydroxylation of HIF1α, challenging the belief that this site is dispensable for oxygen-dependent degradation.
bioRxiv · Apr 22, 2025Biochemistry