Mitsuhiko Ikura

CD33 and Clusterin Interact Biophysically and Genetically to Modulate Alzheimer Risk

This study shows how non-coding variants in CD33 affect Alzheimer's risk by altering CD33M dimerization and interactions with clusterin and Aβ, impacting microglial function.

eIF2B Selectively Anchors and Activates Mutant KRAS

This paper shows eIF2B activates mutant KRAS by forming a complex with SOS at the plasma membrane and regulating glycosphingolipid biosynthesis.

α-catenin phosphorylation is actomyosin-sensitive and required for epithelial barrier functions through Afadin

This study shows that α-catenin phosphorylation, regulated by actomyosin contractility, is essential for epithelial barrier function through its interaction with Afadin.

Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain

The paper identifies PHD2 mutations that affect N-terminal prolyl-hydroxylation of HIF1α, challenging the belief that this site is dispensable for oxygen-dependent degradation.