Combination Treatment with NCX 4040 and Napabucasin Triggers Enhanced Oxidative Stress, STAT3 Inhibition and Plausible Immunogenic Activation in Metastatic Prostate Cancer Cells
Nishtha Pathak, Shrushti Shah, Jeffrey Mathew, Gnanasekar Munirathinam
This study shows that combining NCX 4040 and Napabucasin reduces prostate cancer cell viability, induces oxidative stress, inhibits STAT3, and activates immunogenic pathways.
bioRxiv · Sep 9, 2025 · PreprintPharmacology & Toxicology