Beta-lactam enhancement against methicillin-resistant Staphylococcus aureus by cell wall blockade is autolysis-dependent: a butyrolactone derivative as case in point
Pradnya M Magdum, Jenny N Grissom, Brendan T Franey, Saif Ullah, May H. Abdelaziz, Jeffrey North, Aurijit Sarkar
The paper identifies autolytic ability as a key factor in beta-lactam potentiation against MRSA by blocking cell wall precursor production through a mechanism distinct from the Lipid II pathway.
bioRxiv · Sep 28, 2026 · PreprintMicrobiology