Sticky enzymes: increased metabolic efficiency via substrate-dependent enzyme clustering
Alejandro Martínez-Calvo, Jello Zhou, Yaojun Zhang, Ned S. Wingreen
This paper proposes a self-organization strategy for enzyme clustering based on substrate-dependent stickiness, showing significant increases in pathway flux and reductions in toxic metabolites.
PRX Life · Jul 16, 2025Peer-reviewedBiophysics