Ned S. Wingreen

This study shows that antibody-mediated antigen tethering helps balance affinity and diversity in germinal center B cells by improving robustness during affinity maturation.

This study shows that curved Vibrio cholerae cells swim more efficiently through mucus-like hydrogels than straight mutants, with curvature enhancing chemotaxis by reducing stalls.

The paper reports an in vitro system of lipid kinases and phosphatases that self-organize into dynamic spatiotemporal patterns on model membranes.

The paper introduces a minimal model to explain how temperate phages make lysis-lysogeny decisions based on multiplicity of infection and host factors, showing how asymmetry can arise from simple coupling to host machinery.

This study demonstrates the formation of large-scale polar microtubule swarms that enable dense molecular transport through motor-driven activity and filament regeneration.

The paper shows that phenotypic heterogeneity in yeast populations is an evolutionarily stable strategy that maximizes long-term fitness under environmental changes.

The paper shows that plasmid-dependent phages can help high-cost plasmids persist by reducing their abundance and neutralizing their costs in host populations.

This study develops a theoretical framework to show how membrane-anchored mobile tethers influence condensate wetting, localization, and migration by modifying surface tension and contact angle.

The paper shows that virus-like particle-displayed antigens bypass BCR tolerance by triggering distinct signaling and transcriptional programs compared to soluble antigens.

This study shows Pseudomonas aeruginosa uses different antagonistic strategies to outcompete Burkholderia cenocepacia and Staphylococcus aureus, depending on the competitor's growth rate.

This study identifies the kinase KEY1 as a regulator of pyrenoid condensate size and dynamics in Chlamydomonas reinhardtii, showing it disrupts phase separation interactions to control condensate dissolution during the cell cycle.

The paper shows that bacterial chemotaxis allows Escherichia coli to form fronts that escape phage predation without resistance.

The paper develops a population dynamics model of B and TFH cells in germinal centers, showing reciprocal stimulation regulates their ratio and balances affinity maturation speed with B cell diversity.

The paper quantifies T cell response dynamics during primary SARS-CoV-2 infection, showing clone-intrinsic properties drive clonal kinetics and providing insights for vaccine design.

This study develops a multi-nutrient differential equation model to show how competitive catabolism between glucose, fatty acids, and ketones under fasting conditions leads to systemic metabolic homeostasis, with implications for obesity-induced diabetes.

This paper demonstrates a boundary-sensing mechanism in branched microtubule networks using a nanotechnology platform, showing how length-dependent branching and dynamic instability enable tunable network formation in confined spaces.

This study shows capillary forces organize bacterial colonies into dense, nematic groups and influence their collective dynamics.

This paper proposes a self-organization strategy for enzyme clustering based on substrate-dependent stickiness, showing significant increases in pathway flux and reductions in toxic metabolites.

The paper investigates why waste-product cross-feeding persists in microbial communities by developing a mathematical model showing that intracellular metabolite toxicity can make cross-feeding evolutionarily stable.

This study uses smFISH to analyze gene expression in V. cholerae biofilms, revealing spatiotemporal patterns and the role of quorum sensing and c-di-GMP signaling in matrix gene expression.

This study shows that bacterial colonies form serpentine 'cables' in polymer-rich environments due to entropic attraction and hindered diffusion, revealing new principles of morphogenesis in complex media.

The paper develops a mathematical model to study bacterial-phage coexistence, showing stable coexistence arises from evolutionary dynamics of defense and counter-defense systems.

The paper shows that polysome dynamics in E. coli help segregate chromosomes during cell division, linking this process to cell growth.

This study develops a theoretical model showing that season length and development time can drive the emergence and coexistence of social and solitary behaviors in insects.

The paper shows that bacterial species use distinct microcolony morphologies to colonize surfaces under high fluid flow, with S. aureus relying on signaling molecules and E. faecalis on mechanical forces.

The paper quantifies translational regulation in E. coli across 12 conditions, revealing gene-specific and cross-condition variability in translation efficiency.

The paper quantifies protein turnover in E. coli under 12 conditions, revealing cytoplasmic protein recycling under nitrogen limitation and identifying unknown proteolysis pathways.

The paper shows C. elegans piRNAs functionally target sequence space randomly, enabling broad silencing of nonself sequences.

The paper identifies YhdP as a modulator of phospholipid transport rate in Escherichia coli, showing its role in controlling inner membrane shrinkage and outer membrane rupture during mlaA* mutation.

This study models microbial metabolic trade-offs in a chemostat to show how dynamic fitness landscapes enable ecological and evolutionary stable coexistence.