Predicting Antibody Self-Association with Sequence Structure Fusion Models: The Central Role of CSI-BLI in Early Developability Screening
Shafayat Ahmed, Federico Devalle, Lauren Leisen, Tony Pham, Bismark Amofah, Amber N. Lee, Mark Hutchinson, Chacko Chakiath, Jen DiChiara, Sharfa Farzandh, Madi Kreitz, Alison Hinton, Neil Mody, Andrew B. Dippel, Gilad Kaplan, Maryam Pouryahya
The paper develops a sequence-structure fusion model to predict antibody self-association using CSI-BLI data, achieving high performance in distinguishing high and low self-interacting clones.
mAbs · Jul 8, 2026Peer-reviewedBioinformatics