Tony Pham

The paper develops a sequence-structure fusion model to predict antibody self-association using CSI-BLI data, achieving high performance in distinguishing high and low self-interacting clones.

This paper introduces LAffAb, a method to co-optimize antibody affinity and stability through combinatorial mutation design, achieving significant affinity gains while maintaining developability.

This study uses DeepAb to design antibody variants with enhanced stability and affinity without antigen information, showing 91% and 94% improvements in thermal/colloidal stability and affinity, respectively.