Author

Andrew B. Dippel

AstraZeneca (United States)ORCID 0000-0003-3453-0803Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Molecular Biology· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Assay:protein sequence· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Research Focus:protein design· 1

Frequent Co-Authors

Gilad KaplaniD· 2 shared Tony PhamiD· 2 shared Alison Hinton· 1 shared Amber N. LeeiD· 1 shared Bismark AmofahiD· 1 shared Chacko Chakiath· 1 shared Federico DevalleiD· 1 shared Fitnat H. YildiziD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersBioinformatics

Gilad KaplanORCID

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Author profile →

3 papers

Recent·Most cited

Predicting Antibody Self-Association with Sequence Structure Fusion Models: The Central Role of CSI-BLI in Early Developability Screening

Shafayat Ahmed, Federico Devalle, Lauren Leisen, Tony Pham, Bismark Amofah, Amber N. Lee, Mark Hutchinson, Chacko Chakiath, Jen DiChiara, Sharfa Farzandh, Madi Kreitz, Alison Hinton, Neil Mody, Andrew B. Dippel, Gilad Kaplan, Maryam Pouryahya

The paper develops a sequence-structure fusion model to predict antibody self-association using CSI-BLI data, achieving high performance in distinguishing high and low self-interacting clones.

mAbs · Jul 8, 2026Peer-reviewedBioinformatics

Enhancement of antibody thermostability and affinity by computational design in the absence of antigen

Mark Rowland Hutchinson, Jeffrey A. Ruffolo, Nantaporn Haskins, Michael J. Iannotti, Giuliana Vozza, Tony Pham, Nurjahan Mehzabeen, Harini Shandilya, Keith W. Rickert, Rebecca Croasdale-Wood, Melissa M. Damschroder, Ying Hui Fu, Andrew B. Dippel, Jeffrey J. Gray, Gilad Kaplan

This study uses DeepAb to design antibody variants with enhanced stability and affinity without antigen information, showing 91% and 94% improvements in thermal/colloidal stability and affinity, respectively.

mAbs · Jun 20, 2024Peer-reviewedMolecular Biology

Ratiometric bioluminescent sensors towards in vivo imaging of bacterial signaling

Andrew B. Dippel, Wyatt A. Anderson, Jin Hwan Park, Fitnat H. Yildiz, Ming Chen Hammond

This paper develops a ratiometric bioluminescent biosensor to image cyclic di-GMP levels in bacteria during host infection.

ACS Chemical Biology · Mar 18, 2020Peer-reviewedSynthetic Biology