Author

Jennifer A. Doudna

Primary ORCID profile (0000-0001-9161-999X · 43 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Jennifer A. DoudnaiD43 papers · QB3

Biology Disciplines

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Research Focus:chromatin & epigenetic regulation· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

Digvijay SinghiD· 1 shared Jingyi FeiiD· 1 shared Samuel H. Sternberg· 1 shared Taekjip HaiD· 1 shared

Activity by Year

2016-2016 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 6 mutual co-author links

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1 shared paperBiophysics

Digvijay SinghORCID

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1 paper

Recent·Most cited

Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9

Digvijay Singh, Samuel H. Sternberg, Jingyi Fei, Taekjip Ha, Jennifer A. Doudna

The paper uses single-molecule FRET to study how mismatches affect Cas9-RNA DNA binding and rejection kinetics, revealing that proximal mismatches lead to rapid rejection while distal mismatches allow stable complex formation.

Nature Communications · Sep 14, 2016Peer-reviewedBiophysics