Methylation at nucleotide C62 in spliceosomal RNA U6 alters mRNA splicing which is important for embryonic development
Allison N. Ogren, Nataliya Kibiryeva, Jennifer A. Marshall, James E. O’Brien, Douglas C. Bittel
The paper shows that SNORD94 regulates 2-O-ribose methylation at C62 in U6 RNA, affecting splicing and contributing to congenital heart defects.
bioRxiv · Jun 5, 2019 · PreprintGenetics