Author

James E. O’Brien

Children's Mercy HospitalORCID 0000-0003-1420-4656Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Organism:zebrafish· 1

Frequent Co-Authors

Douglas C. BitteliD· 2 shared Nataliya KibiryevaiD· 2 shared Alison G. PaquetteiD· 1 shared Allison N. OgreniD· 1 shared Jennifer A. Marshall· 1 shared Jennifer Marshall· 1 shared Kasey C. VickersiD· 1 shared Lan N. TuiD· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersDevelopmental Biology

Douglas C. BittelORCID

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2 papers

Recent·Most cited

Developmental BiologyJournal of the American Heart AssociationPeer-reviewedAug 24, 2022

microRNA Expression Levels Change in Neonatal Patients During and After Exposure to Cardiopulmonary Bypass

Lance Y. Hsieh, Lan N. Tu, Alison G. Paquette…·Vishal Nigam

The paper identifies miRNA expression changes in neonatal patients during and after cardiopulmonary bypass, linking them to inflammation and signal transduction pathways.

3 citations

humanbulk RNA-seq

𝕏 PostBluesky

GeneticsbioRxivPreprintJun 5, 2019

Methylation at nucleotide C62 in spliceosomal RNA U6 alters mRNA splicing which is important for embryonic development

Allison N. Ogren, Nataliya Kibiryeva, Jennifer A. Marshall…·Douglas C. Bittel

The paper shows that SNORD94 regulates 2-O-ribose methylation at C62 in U6 RNA, affecting splicing and contributing to congenital heart defects.

DOI 10.1101/661876

humanzebrafish

𝕏 PostBluesky