Prenatal THC exposure disrupts mitochondrial respiratory gene programs and medium spiny neuron maturation trajectories in the nucleus accumbens
Zhong Chen, Wanqiu Chen, Yun Seok Lee, Wendell Jones, Laura M. Goetzl, Jennifer Dawn Thomas, Yan Dong, Charles Wang
This study shows that prenatal THC exposure disrupts mitochondrial gene programs and medium spiny neuron maturation in the nucleus accumbens using snRNA-seq and snATAC-seq in a rat model.
bioRxiv · Jun 19, 2026 · PreprintNeuroscience