Protein interaction analysis of Plasmodium falciparum circumsporozoite protein variants with human immunoproteins explains RTS,S vaccine efficacy in Ghana
Cheikh Cambel Dieng, Colby T. Ford, Anita Lerch, Dickson Donu, Jennifer Huynh, Kovidh Vegesna, Jun‐tao Guo, Daniel A. Janies, Linda Eva Amoah, Yaw Asare Afrane, Eugenia Y. Y. Lo
The paper analyzes Plasmodium falciparum CSP variants' interactions with human immunoproteins to explain RTS,S vaccine efficacy in Ghana, finding that peptide length affects binding affinity and immune response.
Infection Genetics and Evolution · Feb 24, 2023Peer-reviewedBioinformatics