Targeted protein degradation in lysosome utilizing naturally produced bifunctional antibodies with high levels of mannose 6-phosphate glycans
Andrew C. Hedman, Shou Liu, Jennifer Srnak, Riley N. Marcinczyk, Stephanie Do, Linda Lyons, Stuart Kornfeld, Hung Do, Lin Liu
This paper develops a method to produce bifunctional antibodies with high mannose 6-phosphate glycans for lysosomal degradation of target proteins.
bioRxiv · Sep 3, 2024 · PreprintBiochemistry