Design of highly functional genome editors by modeling the universe of CRISPR-Cas sequences
Jeffrey A. Ruffolo, Stephen Nayfach, Joseph P. Gallagher, Aadyot Bhatnagar, Joel Beazer, Riffat Hussain, Jordan Russ, Jennifer Yip, Emily Hill, Martin Pačesa, Alexander J. Meeske, Peter Cameron, Ali Madani
Language models trained on over one million mined CRISPR operons generated Cas9-like effectors and matching guide RNAs, and an AI-designed editor is reported to edit the human genome precisely.
bioRxiv · Apr 22, 2024 · PreprintSynthetic Biology