Adapting protein language models for structure-conditioned design
Jeffrey A. Ruffolo, Aadyot Bhatnagar, Joel Beazer, Stephen Nayfach, Jordan Russ, Emily Hill, Riffat Hussain, Joseph P. Gallagher, Ali Madani
This paper introduces proseLM, a protein design method that adapts language models with structural and functional context, improving residue recovery and experimental performance in genome editing and antibody design.
bioRxiv · Aug 3, 2024 · PreprintBioengineering