Computational design of pH-sensitive binders
Green Ahn, Brian Coventry, Ella Haefner, Shayan Sadre, Jenny Hu, Mimosa Van, Buwei Huang, Isaac Sappington, Adam J. Broerman, Mauriz A. Lichtenstein, Matthias Glögl, Inna Goreshnik, Dionne K. Vafeados, David A. Baker
This paper introduces computational methods to design pH-sensitive binders that dissociate under acidic conditions, demonstrating their application in targeting various receptors and proteins.
bioRxiv · Sep 29, 2025 · PreprintBiochemistry