Mauriz A. Lichtenstein

Host-derived bile acids drive dysbiosis by selecting bile-resistant epimerizing bacteria in inflammatory bowel disease

The paper identifies epimerized host-derived bile acids as a driver of dysbiosis in IBD by selecting for bile-resistant bacteria that disrupt host bile acid feedback signaling.

Targeting peptide-MHC complexes with designed T cell receptors and antibodies

This paper introduces ADAPT, a deep learning framework for designing TCRs and antibodies that bind to specific pMHC targets, validated through cryo-EM structures and functional testing.

Computational design of pH-sensitive binders

This paper introduces computational methods to design pH-sensitive binders that dissociate under acidic conditions, demonstrating their application in targeting various receptors and proteins.

Design of facilitated dissociation enables control over cytokine signaling duration

The paper designs proteins with controlled dissociation rates by introducing strained excited states, enabling rapid cytokine receptor dissociation.

Bottom-up reconstruction of functional Death Domain Signalosomes reveals a requirement for polymer stability and avidity

The paper constructs a synthetic signalosome using Death Domains and shows that its function depends on polymer stability and avidity, demonstrating these properties are tunable and not restricted to specific motifs.