Embryonic Stem Cell-Specific Responses to DNA Replication Stress
Ryan C. James, Jerry K. Wang, Siddhanth R. Bhatt, Sophie E. Shadid, Daryl J. Phuong, John C. Schimenti
This study investigates how mouse embryonic stem cells respond to DNA replication stress, finding they survive via ATR- and CHK1-dependent mechanisms but lack a strong G2/M checkpoint and repair DNA crosslinks in S phase.
bioRxiv · May 16, 2025 · PreprintCell Biology