Author

Ryan C. James

Cornell UniversityORCID 0000-0002-6162-1009Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Andrew P. JacksoniD· 1 shared Daryl J. PhuongiD· 1 shared Durga Pokharel· 1 shared Gavin S. McNeeiD· 1 shared Grant S. StewartiD· 1 shared Jerry K. Wang· 1 shared Jing ZhangiD· 1 shared John C. SchimentiiD· 1 shared

Activity by Year

2020-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Andrew P. JacksonORCID

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2 papers

Recent·Most cited

Cell BiologybioRxivPreprintMay 16, 2025

Embryonic Stem Cell-Specific Responses to DNA Replication Stress

Ryan C. James, Jerry K. Wang, Siddhanth R. Bhatt…·John C. Schimenti

This study investigates how mouse embryonic stem cells respond to DNA replication stress, finding they survive via ATR- and CHK1-dependent mechanisms but lack a strong G2/M checkpoint and repair DNA crosslinks in S phase.

DOI 10.1101/2025.05.16.654332

mouseDNA methylation

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Molecular BiologyNature CommunicationsPeer-reviewedAug 7, 2020

DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain

Jing Zhang, Marina A. Bellani, Ryan C. James…·Michael M. Seidman

The paper identifies two distinct replisomes, one associated with DONSON in early S phase and euchromatin, and another with FANCM in late S phase and heterochromatin.

42 citations

humanChIP-seq

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