MHCII+ cancer-associated fibroblasts promote antitumor immunity in pancreatic cancer
Jessica Hung, Stephanie Silveria-Davies, Jenna Vickery, Brenna Gittins Maker, Chloe Mikolajczyk, Dorothee Saddier Axe, Brian M. Weist, Joshua E. Elias, Michel DuPage
This study shows that MHCII+ cancer-associated fibroblasts (CAFs) in pancreatic cancer can promote antitumor immunity through IFNγ-driven mechanisms, counteracting Treg suppression.
bioRxiv · Nov 4, 2026 · PreprintImmunology