Co-Targeting Nuclear Export and Translation Initiation Uncovers a Therapeutic Vulnerability in Lethal Prostate Cancer
Jessica D. Kindrick, Kinjal P. Bhadresha, Xiaohu Zhang, Erica L. Beatson, Spencer S. Gaut, Benjamin C. Brim, Patrick J. Signorelli, Roger D. Depaz, Jessica L. Horner, Posey S Whidden, John M. Ching, Kelli Wilson, Savannah Wood, Crystal G. McKnight, Erin Beck, , William D. Figg
This study identifies co-inhibition of XPO1 and EIF4A1 as a therapeutic strategy for mCRPC, showing synergistic antitumor effects at reduced drug doses.
bioRxiv · May 7, 2026 · PreprintCancer Biology