Spatial proteomics of Onchocerca volvulus with pleomorphic neoplasms shows local and systemic dysregulation of protein expression
Lucía Sánchez Di Maggio, Kerstin Fischer, Bruce A. Rosa, Devyn Yates, Byoung-Kyu Cho, Jessica Lukowski, Antonia Zamacona Calderon, Minsoo Son, Young Ah Goo, Nicholas Obuobisa Opoku, Gary J. Weil, Makedonka Mitreva, Peter Fischer
The paper identifies proteins dysregulated in pleomorphic neoplasms of Onchocerca volvulus using mass spectrometry and laser capture microdissection, showing systemic protein expression changes associated with tumor development and worm mortality.
PLoS neglected tropical diseases · Mar 31, 2025Peer-reviewedMolecular Biology