BiochemistrybioRxiv
The Origin of Coupled Chloride and Proton Transport in a Cl-/H+ Antiporter
Sangyun Lee, Heather B. Mayes, Jessica M. J. Swanson, Gregory A Voth
This study uses multiscale simulations to reveal how Cl- binding modulates proton transport in ClC-ec1 by altering the conformation and deprotonation of glutamic acid 148.
DOI 10.1021/jacs.6b06683